... organ-on-a-chip developments allow for a more detailed exploration of these mechanisms. This article examines the results of using these proteins and their potential in the development of innovative creams and serums for skin rejuvenation. Understanding how young blood and bone marrow affect skin condition could open new horizons in anti-aging therapy. German Scientists Demonstrate on a "Organ-on-a-Chip" Model That Proteins Secreted by Young Bone Marrow Under Serum Influence Stimulate Skin Rejuvenation: ...

... healthy mice was administered a small dose of the "harmful" reduced form of HMGB1. The result astonished the scientists. Typically, age-related changes develop over years, but in this instance, clear signs of premature aging appeared in the young animals within just one week. Their cells slowed down in division, the levels of inflammatory molecules in the blood increased, and the physical condition of the mice deteriorated. In simpler terms, the organism reacted as if it had aged suddenly. Moreover, in an additional verification, the researchers compared the blood of elderly individuals (70-80 years) to ...